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You are here:Home » Antibodies » Abs to Transcription Factors, Forkhead (FOX) » Anti -FOXP3 (Forkhead Box P3, AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID) (FITC)

Anti -FOXP3 (Forkhead Box P3, AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID) (FITC)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
One of the many immunotolerance mechanisms that the immune system has developed to distinguish between self and non-self antigens is regulatory T cells or Tregs. Several elegant experiments using transgenic mice and retrovirus-mediated over expression studies, have led to the identification of FOXP3, a trascription factor, as a specific molecular marker essential for the development and function of Tregs. The primary evidence regarding the involvement of FOXP3 in the development of Tregs was provided in patients suffering from IPEX, a rare and fatal human autoimmune disease. The emergence of Tregs and the role of FOXP3 as a critical player in the negative control of various normal and pathological immune responses holds great promise for the development of novel therapies for autoimmune diseases.
Catalog #F9050-10M
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry (Intracellular): 10ul labels1x10e6 cells
Optimal dilutions to be determined by the researcher.
Positive ControlHuman PBMC, mouse splenocytes
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. FITC conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No8k255
HostMouse
SourceMouse
ConcentrationNot determined
FormSupplied as a liquid in 10mM Tris, 150mM sodium chloride, 0.05% BSA, 0.05% sodium azide. Labeled with FITC.
PurityPurified by Protein G affinity chromatography.
ImmunogenFull-length His-tagged mouse FOXP3. The precise epitope is not known, but it has been mapped to the N-terminal portion (aa2-136) of the protein.
SpecificityRecognizes mouse FOXP3. Species Crossreactivity: human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesScurfin


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