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You are here:Home » Antibodies » Abs to Transcription Factors, Forkhead (FOX) » Anti -FOXP3 (Forkhead Box P3, AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX, SCURFIN, XPID)

Anti -FOXP3 (Forkhead Box P3, AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX,
SCURFIN, XPID)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
One of the many immunotolerance mechanisms that the immune system has developed to distinguish between self and non-self antigens is regulatory T cells or Tregs. Several elegant experiments using transgenic mice and retrovirus-mediated over expression studies, have led to the identification of FoxP3, a transcription factor, as a specific molecular marker essential for the development and function of Tregs. The primary evidence regarding the involvement of FoxP3 in the development of Tregs was provided in patients suffering from IPEX, a rare and fatal human autoimmune disease. The emergence of Tregs and the role of FoxP3 as a critical palyer in the negative control of various normal and pathological immune responses hold great promise for the development of novel therapies for autoimmune diseases.
Catalog #F9050-10S
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 2-5ug/ml
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
Positive ControlTransfected cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity Chromatography.
ImmunogenSynthetic peptide corresponding to the exon 2 deletion site.
SpecificityRecognizes FOXP3. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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