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You are here:Home » Antibodies » Abs to Transcription Factors, Forkhead (FOX) » Anti -FOXP3 (Forkhead Box P3, AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX, SCURFIN, XPID) (APC)

Anti -FOXP3 (Forkhead Box P3, AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX,
SCURFIN, XPID) (APC)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
One of the many immunotolerance mechanisms that the immune system has developed to distinguish between self and non-self antigens is regulatory T cells or Tregs. Several elegant experiments using transgenic mice and retrovirus-mediated over expression studies, have led to the identification of FOXP3, a transcription factor, as a specific molecular marker essential for the development and function of Tregs. The primary evidence regarding the involvement of FOXP3 in the development of Tregs was provided in patients suffering from IPEX, a rare and fatal human autoimmune disease. The emergence of Tregs and the role of FOXP3 as a critical player in the negative control of various normal and pathological immune responses holds great promise for the development of novel therapies for autoimmune diseases.
Catalog #F9050-12A
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry (Intracellular): 10ul/1x10e6 cells
Optimal dilutions to be determined by the researcher.
Positive ControlMouse thymocytes, human PBMCs
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No11E198
HostMouse
SourceMouse
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide. Labeled with Allophycocyanin (APC).
PurityPurified by Protein G affinity chromatography.
ImmunogenFull-length His-tagged murine FOXP3.
SpecificityRecognizes mouse FOXP3. Species Crossreactivity: human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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