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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified B

G6B is a 241aa novel regulatory nuclear chloride ion channel protein belonging to the immunoglobulin (Ig) super family. It is a glycosylated receptor, present both as soluble and transmembrane isoforms where the soluble proteins show expression in endoplasmic reticulum and Golgi before being secreted. It contains a leader sequence and an extracellular Ig domain which binds to heparin and helps to modulate the interaction of G6B with an unknown protein ligand. It also has an intracellular, proline-rich potential SH3-binding domain, and two putative phosphorylated tyrosine motifs with an SH2-binding domain that is recruited to the receptor and dephosphorylates membrane-bound phosphoproteins and thus modulates the signaling cascade. It is commonly expressed in certain hematopoietic cell lines including K562, Molt4, and Jurkat.
Catalog #	G0900-24
Applications	Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution	Western Blot: 0.5-2ug/ml
	Optimal dilutions to be determined by the researcher.
Positive Control	K562 cell lysate
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	~0.5mg/ml
Form	Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide corresponding to aa1-50 of human G6B.
Specificity	Recognizes human G6B. Species Crossreactivity
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.