Anti -G9a, ID (Histone-lysine N-methyltransferase, H3 Lysine-9 Specific 3, Histone H3-K9
Methyltransferase 3, H3-K9-HMTase 3, Euchromatic Histone-lysine N-methyltransferase 2,
HLA-B Associated Transcript 8, G9a Protein, EHMT2, Lysine N-methyltransferase 1C, NG3
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
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| A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. The gene for G9a is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described BAT8, also known as G9A, is a lysine-preferring histone methyltransferase. H3 Lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. The presence of the ankyrin repeats also suggests that BAT8 is involved in intracellular protein-protein interaction. Like Suv39h1, BAT8 transfers methyl groups to the lysine residues of histone H3, but with a 10- to 20-fold higher activity. BAT8 was able to add methyl groups to lys27 as well as lys9 in histone H3, compared with Suv39h1, which was able only to methylate lys9. BAT8 is localized to the nucleus but not in the repressive chromatin domains of centromeric loci, in which Suv39h1 family proteins were localized. This protein is probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. BAT8 also methylates histone H1. | | | Catalog # | G1009-02D | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:1,000 | | Western Blot: 1:100-1:500 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.25mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide selected from the center region of human G9a (KLH). | | Specificity | Recognizes human KMT1C. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -G9a, ID (Histone-lysine N-methyltransferase, H3 Lysine-9 Specific 3, Histone H3-K9 Methyltransferase 3, H3-K9-HMTase 3, Euchromatic Histone-lysine N-methyltransferase 2, HLA-B Associated Transcript 8, G9a Protein, EHMT2, Lysine N-methyltransferase 1C, NG3 |
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