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You are here:Home » Antibodies » Abs to Amino Acids » Anti -GABA (Gamma-aminobutyrIc Acid)

Anti -GABA (Gamma-aminobutyrIc Acid)

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Specifications

Clone Host Grade Applications
Polyclonal Guinea pig Serum E IH
Gamma-aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays a role in regulating neuronal excitability throughout the nervous system. In humans, GABA is also directly responsible for the regulation of muscle tone. Although chemically it is an amino acid, GABA is rarely referred to as such in the scientific or medical communities, because the term "amino acid," used without a qualifier, conventionally refers to the alpha amino acids, which GABA is not, nor is it ever incorporated into a protein. In spastic diplegia in humans, GABA absorption becomes impaired by nerves damaged from the condition's upper motor neuron lesion, which leads to hypertonia of the muscles signaled by those nerves that can no longer absorb GABA.
Catalog #G1015-05C
ApplicationsSuitable for use in ELISA and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry (Formalin-Fixed, Paraffin Embedded using heat-induced epitope retrieval): 1:500
Optimal dilutions to be determined by the researcher.
Recommended Positive ControlRat brain tissue
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGuinea pig
ConcentrationNot Determined
FormSupplied as a liquid in 0.1M Tris-Glycine, 0.15M sodium chloride, pH 7.4 0.05% sodium azide
PuritySerum
ImmunogenGABA coupled to BSA via glutaraldehyde
SpecificityRecognizes GABA. Staining was blocked by preabsorbing with 100uM GABA conjugated to glutaraldehyde. 500uM of similar conjugations of glutamic acid, glutamate and taurine failed to block staining. Species Crossreactivity: rat. Expected to react with all species.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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