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Specifications

Clone Host Grade Applications Polyclonal Guinea pig Serum IH

Gamma-aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays a role in regulating neuronal excitability throughout the nervous system. In humans, GABA is also directly responsible for the regulation of muscle tone (6). Although chemically it is an amino acid, GABA is rarely referred to as such in the scientific or medical communities, because the term "amino acid," used without a qualifier, conventionally refers to the alpha amino acids, which GABA is not, nor is it ever incorporated into a protein. In spastic diplegia in humans, GABA absorption becomes impaired by nerves damaged from the condition's upper motor neuron lesion, which leads to hypertonia of the muscles signaled by those nerves that can no longer absorb GABA.
Catalog #	G1015-05C
Applications	Suitable for use in Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions	Immunohistochemistry (frozen): 1:1000 (FITC and HRP methods)
	Optimal dilutions to be determined by the researcher.
Recommended Control	Brain tissue
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Guinea pig
Concentration	Not determined
Form	Supplied as a liquid.
Purity	Serum
Immunogen	GABA coupled to KLH via glutaraldehyde
Specificity	Recognizes GABA. Staining was blocked by preabsorbing with 100uM GABA conjugated to glutaraldehyde. 500uM of similar conjugations of glutamic acid, glutamate and taurine failed to block staining. Species Crossreactivity: mammal
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.