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You are here:Home » Antibodies » Abs to Ion Channel » Anti -GABA Receptor A, alpha1 (Gamma-aminobutyric Acid Receptor Type A alpha 1 Subunit, GABRA1)

Anti -GABA Receptor A, alpha1 (Gamma-aminobutyric Acid Receptor Type A alpha 1 Subunit,
GABRA1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IC
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all
biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the
passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand-gated, other gating systems and finally those that are
classified differently, having more exotic characteristics. The first are voltage- gated ion channels
which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as
ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). The GABA-A receptor is a member of the superfamily of fast
acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (3). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (4).
Catalog #G1015-06W
ApplicationsSuitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1-10ug/ml
Immunocytochemistry: 0.1-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2A
Clone No10F702
HostMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH7.4, 50% glycerol and 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenFusion protein aa 355-394 of mouse GABA-A-R-Alpha1, accession number P62812.
SpecificityRecognizes mouse GABA-A-R-Alpha1. Species Crossreactivity: human, rat. No cross-reactivity against GABA-A-R-Alpha2 or –Alpha3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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