Anti -Galectin-3 (Galactose-specific Lectin 3, Galectin 3, GAL3, Gal-3, 35kD Lectin,
Carbohydrate Binding Protein 35, CBP 35, CBP35, Galactoside Binding Protein, GALBP, GALIG,
IgE Binding Protein, L31, L-31, Laminin Binding Protein, Lectin Galactoside Binding S
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH FC |
|
| Galectin-3 is a member of the galectin family. The protein is composed of three domains: a small amino-terminal domain, a carboxyl-terminal carbohydrate recognition domain (CRD) and amino-terminal domain containing repeating elements. Galectin-3 is normally distributed in epithelia of many organs and various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins. The expression is also affected by neoplastic transformation: up-regulated in certain types of lymphomas and thyroid carcinoma, while down-regulated in other types of malignancies, such as colon, breast, ovarian and uterine carcinomas. Galectin-3 has been shown to function through both intracellular and extracellular actions. Related to its intracellular functions, galectin-3 has been identified as a component of heterogeneous nuclear ribonuclear protein (hnRNP), a factor in pre-mRNA splicing, and has been found to control cell cycle and prevent T cell apoptosis. On the other hand, this protein has also been demonstrated to function as extracellular molecule in activating various types of cells, including monocytes/macrophages, mast cells, neutrophils and lymphocytes. Galectin-3 has been shown to mediate cell-cell and cell-extracellular matrix interactions. | | | The monoclonal antibody inhibits the binding of 125I-labeled galectin-3 to IgE coated on microtiter plates, the galecin-3’s hemagglutination activity and galectin-3-induced superoxide production by human neutrophils. This inhibitory activity of B2C10 is probably the result of its disruption of the self-association process. | | | Catalog # | G1044-50G | | Applications | Suitable for use in Flow Cytometry, ELISA, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 1:50 | | Western Blot: 1:50 | | Immunohistochemistry (Frozen, paraffin): 1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | B2C10 | | Host | Mouse | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, 0.1% BSA. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Galectin-3 | | Specificity | Recognizes human Galectin-3, a 30kD protein. The epitope is found within the first 45aa of galectin-3. Does not react with Galecin-3C. Species Crossreactivity: Mouse | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | 35kD Lectin, Carbohydrate-binding Protein 35, Galactose Specific Lectin 3, Galactoside-binding Protein, IgE-binding Protein, Laminin-binding Protein, Lectin Galactoside-binding Soluble 3, LGALS2, MAC 2 Antigen |
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Download Specifications for Anti -Galectin-3 (Galactose-specific Lectin 3, Galectin 3, GAL3, Gal-3, 35kD Lectin, Carbohydrate Binding Protein 35, CBP 35, CBP35, Galactoside Binding Protein, GALBP, GALIG, IgE Binding Protein, L31, L-31, Laminin Binding Protein, Lectin Galactoside Binding S |
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