Anti -Galectin-3 (GAL3, Carbohydrate Binding Protein 35, CBP35, Galactose Specific Lectin
3, Galactoside Binding Protein, GALBP, IgE Binding Protein, Laminin Binding Protein,
Lectin Galactose Binding Soluble 3, LGALS3, MAC2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
E B IH FC IF |
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| Galectins are a new family of animal lectins which appear to exhibit a variety of biological functions and may in fact be a broad-spectrum biological response modifier. Due to a C-terminal carbohydrate binding site, Galectin 3 is capable of binding IgE and mammalian cell surfaces only when homodimerized or homooligomerized. Among its numerous proposed functions, Galectin 3 may be a component of a cell-growth regulating system given its elevated expression and nuclear localization in proliferating cells. It has also been found to be a major non-integrin laminin-binding protein suggesting a role in cell adhesion. One of its more interesting proposed functions is as an inhibitor of apoptosis. Galectin 3 shares an NWGR motif with Bcl-2 which has been shown to be an imjportant region in Bcl-2 for suppression of apoptosis. Galectin 3 has been shown to interact with Bcl-2 which may account for the ability of Galectin 3 to suppress programmed cell death in anti-Fas treated Jurkat cells transfected with Galectin 3. In contrast to Galectin 3, Galectin 1 actually induces apoptosis when added to cultures of activated human T cells. | | | Catalog # | G1044-51 | | Applications | Suitable for use in Immunohistochemistry, Western Blot, ELISA, Flow Cytometry and Immunofluorescence. Other applications not tested. | | Recommended Dilutions | Immunohistochemistry: (Paraffin): 6ug/ml | | Western Blot: 1ug/ml. Detects a ~30kD protein representing Galactin 3 from Jurkat cells transfected with human Galactin 3. | | Optimal dilutions to be determined by the researcher. | | Positive Control | Rat Olfactory bulb | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 4i288 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.05% sodium azide. | | Purity | Purified | | Immunogen | Full length recombinant human Galectin 3. Epitope: aa1-58 of Galectin 3. | | Specificity | Recognizes human Galectin 3 at ~30kD. Species Crossreactivity: rat and mouse. Immunohistochemistry staining of Galectin 3 in rat olfactory bulb yields a pattern consistant with nuclear and plasma membrane staining. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Galectin-3 (GAL3, Carbohydrate Binding Protein 35, CBP35, Galactose Specific Lectin 3, Galactoside Binding Protein, GALBP, IgE Binding Protein, Laminin Binding Protein, Lectin Galactose Binding Soluble 3, LGALS3, MAC2) |
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