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You are here:Home » Antibodies » Abs to Lectins » Anti -Galectin-3 (GAL3, Carbohydrate Binding Protein 35, CBP35, Galactose Specific Lectin 3, Galactoside Binding Protein, GALBP, IgE Binding Protein, Laminin Binding Protein, Lectin Galactose Binding Soluble 3, LGALS3, MAC2)

Anti -Galectin-3 (GAL3, Carbohydrate Binding Protein 35, CBP35, Galactose Specific Lectin
3, Galactoside Binding Protein, GALBP, IgE Binding Protein, Laminin Binding Protein,
Lectin Galactose Binding Soluble 3, LGALS3, MAC2)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B IH FC IF
Galectins are a new family of animal lectins which appear to exhibit a variety of biological functions and may in fact be a broad-spectrum biological response modifier. Due to a C-terminal carbohydrate binding site, Galectin 3 is capable of binding IgE and mammalian cell surfaces only when homodimerized or homooligomerized. Among its numerous proposed functions, Galectin 3 may be a component of a cell-growth regulating system given its elevated expression and nuclear localization in proliferating cells. It has also been found to be a major non-integrin laminin-binding protein suggesting a role in cell adhesion. One of its more interesting proposed functions is as an inhibitor of apoptosis. Galectin 3 shares an NWGR motif with Bcl-2 which has been shown to be an imjportant region in Bcl-2 for suppression of apoptosis. Galectin 3 has been shown to interact with Bcl-2 which may account for the ability of Galectin 3 to suppress programmed cell death in anti-Fas treated Jurkat cells transfected with Galectin 3. In contrast to Galectin 3, Galectin 1 actually induces apoptosis when added to cultures of activated human T cells.
Catalog #G1044-51
ApplicationsSuitable for use in Immunohistochemistry, Western Blot, ELISA, Flow Cytometry and Immunofluorescence. Other applications not tested.
Recommended DilutionsELISA: 1:100-1:2000
Immunohistochemistry: 1:10-1:2000
Immunohistochemistry: (Paraffin): 6ug/ml
Western Blot: 1ug/ml. Detects a ~30kD protein representing Galactin 3 from Jurkat cells transfected with human Galactin 3.
Immunocytochemistry(Immunofluorescence): 1:10-1:2000
Optimal dilutions to be determined by the researcher.
Positive ControlRat Olfactory bulb
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No4i288
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.05% sodium azide.
PurityPurified
ImmunogenFull length recombinant human Galectin 3. Epitope: aa1-58 of Galectin 3.
SpecificityRecognizes human Galectin 3 at ~30kD. Species Crossreactivity: rat and mouse. Immunohistochemistry staining of Galectin 3 in rat olfactory bulb yields a pattern consistant with nuclear and plasma membrane staining.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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