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You are here:Home » Antibodies » Antibodies-Gangliosides » Anti -Ganglioside GD3, O-acetyl

Anti -Ganglioside GD3, O-acetyl


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH IF
Gangliosides play vital roles in various cellular functions such as cell-cell adhesion, communication, and cell-substrate interactions. The divers sugar groups are generated by different types of O-substitutions, usually O-acetyl esters, of the parent molecules. 6A88 is raised against B49 cell line, and it specifically recognizes O-acetyl gangliosides. O-acetyl ganglioside is found in developing rat embryonic neuroectoderm and many human melanoma cells. In developing rat cerebellum, the O-acetyl ganglioside antigen was localized by immunofluorescence to germinal cells of the external granule layer. The 6A88 antigen is a marker for germinal cells, and the acquisition and subsequent loss of it is an aspect of the biochemical maturation of nervous and glial cells.
Catalog #G2005-50A
ApplicationsSuitable for use in Immunohistochemistry and Immunofluorescence. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry (Frozen): 2-5ug/ml
Immunofluorescence: 2-5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No6A88
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide
PurityPurified by Protein A chromatography
ImmunogenB49 cells
SpecificityRecognizes O-acetyl gangliosides in rat brain tumor and most human malignant melanoma tumors. Does not crossreact with normal human skin melanocytes.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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