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GANT58 (2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503)
GANT58 (2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503)
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| Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC50 ~ 5uM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo. | | | Catalog # | G2008 | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO or ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Protect from light and air. | | CAS Number | 64048-12-0 | | Molecular Formula | C H N S | | Molecular Weight | 392.48 | | Purity | ~98% (HPLC) | | Form | Supplied as a yellow solid. Reconstitute with 25mM ethanol or 25mM DMSO. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | 2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503 |
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