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You are here:Home » Biochemicals » Biochem-Molecular Biology » GANT58 (2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503)

GANT58 (2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503)


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Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC50 ~ 5uM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.
Catalog #G2008
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO or ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Protect from light and air.
CAS Number64048-12-0
Molecular FormulaC H N S
Molecular Weight392.48
Purity~98% (HPLC)
FormSupplied as a yellow solid. Reconstitute with 25mM ethanol or 25mM DMSO.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503

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