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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -GATA1 (GATA Binding Factor 1, GATA Binding Protein 1)

Anti -GATA1 (GATA Binding Factor 1, GATA Binding Protein 1)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B FC
Globin transcription factor 1 (GATA-1) is a transcription activator belonging to the GATA family of transcription factors with importance in cell growth. GATA-1 is a Cys2-Cys2 zinc finger DNA binding protein commonly found in erthroid (red blood cell) and emagkaryotic (platelet producing cell) and it is critical in the development process of both (1). It binds to the consensus sequence of [AT]GATA[AG] within regulatory regions of globin genes and genes in erythroid cells, leading to transcription of alpha spectrin structural protein necessary for red blood cell’s shape. In human, GATA-1 can enhance transcription rate up to 100 times (2). Mutation to GATA-1 encoding gene has been implicated to X-linked dyserythropoietic anemia, thrombocytopenia, Down’s syndrome in children, congenital transient myeloproliferative syndrome, and acute megakaryocytic leukemia (2, 3).
Catalog #G2021-30P
ApplicationsSuitable for use in Western Blot, Flow Cytometry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-2000
Flow Cytometry: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9E325
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
PuritySupernatant
ImmunogenA synthetic peptide corresponding to N-terminus
of human Gata-1
SpecificityRecognizes human GATA1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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