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G2021-33A Rabbit Anti-GATAD2A (GATA Zinc Finger Domain Containing 2A, FLJ20085, p66alpha) (Not for Export EU)

Specifications
Clone Type
Polyclonal
Host
Rabbit
Source
Mouse
Swiss Prot
Q8CHY6
Isotype
IgG
Grade
Serum
Applications
IHC WB
Crossreactivity
Hu Mo Rt
Accession #
AAH19178.1
Shipping Temp
Blue Ice
Storage Temp
-20°C
GATA zinc finger domain containing 2A, GATA zinc finger domain containing protein 2A, Hp66 alpha, Hp66alpha, p66alpha, Transcriptional repressor p66 alpha, Transcriptional repressor p66alpha

Methylation of cytosine at CpG dinucleotides is a common feature of many higher eukaryotic genomes. Increasing evidence indicates that recruitement of histone deacetylase complexes by methyl-CpG-binding proteins (MeCP) is a major mechanism of methylated DNA silencing. P66, a zinc finger-containing protein is one of the components of the MeCP1 complex. P66 and p68, the two components of MeCP1 are different forms of the same zinc finger-containing protein and are conserved from C.elegans to humans. Homologs of p66 from different organisms revealed two highly conserved regions, CR1 and CR2. While CR1 is involved in the association of p66 with other MeCP1 components, CR2 plays an important role in targeting p66 and MBD3 to specific loci.

Applications
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Western Blot: 1:500-1:1000 Immunohistochemistry (paraffin): 1:50 Optimal dilutions to be determined by the researcher.
Positive Control
p66 alpha Knockout HeLa Cell Lysate
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to aa137-150 of mouse p66a.
Form
Supplied as a liquid in 0.05% sodium azide.
Purity
Serum
Specificity
Recognizes mouse p66a. Species Crossreactivity: human and rat
Conjugates
Pricing
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