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Abs to Transcription Factors, Zinc (Ring) Finger
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Anti -GATA4, phosphorylated (Ser105) (GATA Binding Factor 4, GATA Binding Protein 4)
Anti -GATA4, phosphorylated (Ser105) (GATA Binding Factor 4, GATA Binding Protein 4)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| GATA-4 is a 46kD member of the GATA family of zinc finger-containing transcription factors that is involved in the development of cardiac hypertrophy and remodeling; it plays a critical role in regulating basal and agonist or stress-induced gene expression in cardiac and smooth muscle cell types. GATA-4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA-4 is phosphorylated in response to agonist stimulation through MEK1-ERK1/2 and weakly through JNK or p38 MAPKs. | | | Catalog # | G2021-51 | | Applications | Suitable for use in Western Blot. Other applications have not been tested. | | Recommended Dilutions | | | Western Blot: 0.1-1ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Controls Used | Phenylephrine (PE)-stimulated rat cardiomyocytes, transfected with mouse GATA-4. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in Dulbecco’s PBS (without Mg2+ and Ca2+), pH 7.3, 1mg/ml BSA (IgG, protease free), 0.05% sodium azide. | | Purity | Purified by Immunoaffinity chromatography. | | Immunogen | Synthetic phosphopeptide derived from a region of human GATA-4 that contains serine 105. | | Specificity | Recognizes mouse GATA-4 when phosphorylated at Ser105. Species sequence homology: human, rat and chicken (100%). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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