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Specifications

EGFR tyrosine kinase inhibitor that binds to the ATP-binding site of the enzyme. The functions of the EGFR tyrosine kinase in activating the Ras signal transduction cascade and malignant cell growth are thus inhibited. It has been shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways in gefitinib-sensitive non-small cell lung cancers. These mutations tend to increase sensitivity to tyrosine kinase inhibitors including gefitinib and erlotinib. The adenocarcinoma subset of non-small cell lung cancer histologies often have these mutations, which are commonly found in Asians, women, and non-smokers.
Catalog #	G2023-95A
Solubility	Soluble in DMSO, up to about 100mg/ml; very poorly soluble in water or ethanol.
Melting Point	188-193°C
Elemental Analysis	Calculated:
	C - 59.13%
	H - 5.41%
	Cl - 7.93%
	F - 4.25%
	N - 12.54%
Storage and Stability	May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
CAS Number	184475-35-2
Molecular Formula	C22H24ClFN4O3
Molecular Weight	446.90
Purity	~99%
Form	Supplied as a white to off-white powder.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.