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You are here:Home » Biochemicals » Biochem-Antibiotics » Geldanamycin (Streptomyces hygroscopicus) 98+%

Geldanamycin (Streptomyces hygroscopicus) 98+%

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Specifications

Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. A potent antitumor 1 and potent inhibitor of p60c-crc tyrosine kinase, erb B2,2 EGF receptor tyrosine kinase and non-receptor tyrosine kinases. 3, Geldanamycin binds specifically and inhibits the chaperone protein Hsp90.2
Catalog #G2024-50
Geldanamycin acts by binding to the 90kD heat-shock protein (Hsp90) essential to maintain the conformation, stability, activity and cellular localization of several key oncogenic proteins such as ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1alpha, survivin and telomerase hTERT.
Related to Antibiotic TAN 420C, Antibiotic TAN 420E, Herbimycin A, Herbimycin B
Solubility1mg/ml in DMSO
ImpuritiesMajor Impurities: 1%
Total Impurities: 2%
Heavy Metals
0.02%
Storage and Stability Store at -20°C. Stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Protect from light.
CAS Number30562-34-6
Molecular FormulaC29H40N2O9
Molecular Weight560.6
Purity98%
FormSupplied as a yellow, lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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