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Geldanamycin (Streptomyces hygroscopicus) 98+%
Geldanamycin (Streptomyces hygroscopicus) 98+%
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| Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. A potent antitumor 1 and potent inhibitor of p60c-crc tyrosine kinase, erb B2,2 EGF receptor tyrosine kinase and non-receptor tyrosine kinases. 3, Geldanamycin binds specifically and inhibits the chaperone protein Hsp90.2 | | | Catalog # | G2024-50 | | Geldanamycin acts by binding to the 90kD heat-shock protein (Hsp90) essential to maintain the conformation, stability, activity and cellular localization of several key oncogenic proteins such as ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1alpha, survivin and telomerase hTERT. | | Related to | Antibiotic TAN 420C, Antibiotic TAN 420E, Herbimycin A, Herbimycin B | | Solubility | 1mg/ml in DMSO | | Impurities | Major Impurities: 1% | | Total Impurities: 2% | | Heavy Metals | | | 0.02% | | Storage and Stability | Store at -20°C. Stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Protect from light. | | CAS Number | 30562-34-6 | | Molecular Formula | C29H40N2O9 | | Molecular Weight | 560.6 | | Purity | 98% | | Form | Supplied as a yellow, lyophilized powder. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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