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You are here:Home » Antibodies » Abs to DNA Replication, Repair » Anti -Geminin (GMNN, GEM, Geminin DNA Replication Inhibitor, DNA replication inhibitor, RP3 369A17.3)

Anti -Geminin (GMNN, GEM, Geminin DNA Replication Inhibitor, DNA replication inhibitor,
RP3 369A17.3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex. It is degraded during the mitotic phase of the cell cycle, has a destruction box sequence (RRTLKVIQP), and is ubiquitinated by the anaphase promoting complex in vitro. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Further, geminin interacts tightly with CDT1, a replication initiation factor necessary for MCM loading.
Catalog #G2024-55D
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormTris-citrate/phosphate buffer, pH 7 to 8
PurityPurified by immunoaffinity chromatography.
ImmunogenThis antibody maps to a region between residue 50 and 100 of human Geminin DNA replication Inhibitor using the numbering given in entry NP_056979.1 (GeneID 51053).
SpecificitySpecies Crossreactivity: Human. Other species not tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesGMNN, GEM, Geminin DNA Replication Inhibitor, DNA replication inhibitor, OTTHUMP00000039393, RP3 369A17.3


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