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You are here:Home » Antibodies » Antibodies-DNA Replication, Repair » Anti -Geminin (GMNN, GEM, Geminin DNA Replication Inhibitor, DNA replication inhibitor, RP3 369A17.3)

Anti -Geminin (GMNN, GEM, Geminin DNA Replication Inhibitor, DNA replication inhibitor,
RP3 369A17.3)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex. It is degraded during the mitotic phase of the cell cycle, has a destruction box sequence (RRTLKVIQP), and is ubiquitinated by the anaphase promoting complex in vitro. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Further, geminin interacts tightly with CDT1, a replication initiation factor necessary for MCM loading.
Catalog #G2024-55E
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionImmunoprecipitation: 2-5ug/mg lysate
Western Blot: 1:2000-1:10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in Tris-citrate/phosphate buffer, pH 7.5, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
SpecificityRecognizes human Geminin. The epitope maps to a region between residue 160 and the C-terminus (residue 209) of human Geminin DNA replication Inhibitor using the numbering given in entry NP_056979.1 (GeneID 51053).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesGMNN, GEM, Geminin DNA Replication Inhibitor, DNA replication inhibitor, OTTHUMP00000039393, RP3 369A17.3

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