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Anti -GFR alpha1, IN (GDNFRa, Glial Cell-derived Neurotrophic Factor Receptor a1, RETL1, Ret ligand 1, TGFb-related Neurotrophic Factor Receptor 1, TrnR1, Glycosylphosphadidylinositol linked Protein)
Anti -GFR alpha1, IN (GDNFRa, Glial Cell-derived Neurotrophic Factor Receptor a1, RETL1,
Ret ligand 1, TGFb-related Neurotrophic Factor Receptor 1, TrnR1,
Glycosylphosphadidylinositol linked Protein)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
B |
|
| Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF (1,2). The cDNAs encoding GDNFRa from human, rat, chicken and mouse have been cloned recently (1-5). GDNFRa was also termed Ret ligand 1 (RETL1) or TGF-b-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRa-1 recently (5-7). GFRa-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRa and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function. | | | Catalog # | G2033-01 | | This polyclonal antibody can be used for detection of GFRa-1 by Western blot. The amino acid sequence of immunogenic peptide is identical to those of mouse and rat and the antibody recognizes GFRa-1 from human, mouse and rat origins. | | Antibody blocking peptide | G2033-01P. | | | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | 0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified IgG | | Immunogen | Peptide corresponding to amino acids 369 to 382 of human GFRa-1 (1). | | Specificity | Recognizes human GFR alpha-1 (IN). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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