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You are here:Home » Molecular Biology » MB-Neurotrophins » GFR alpha1, IN, Blocking Peptide (GDNFRa, Glial Cell-derived Neurotrophic Factor Receptor a1, RETL1, Ret ligand 1, TGFb-related Neurotrophic Factor Receptor 1, TrnR1, Glycosylphosphadidylinositol linked Protein)

GFR alpha1, IN, Blocking Peptide (GDNFRa, Glial Cell-derived Neurotrophic Factor Receptor
a1, RETL1, Ret ligand 1, TGFb-related Neurotrophic Factor Receptor 1, TrnR1,
Glycosylphosphadidylinositol linked Protein)

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Specifications

Peptide corresponding to amino acids 369 to 382 of human GFRa-1 (1). This peptide is used as the immunogen for catalog no. G2033-01.
Catalog #G2033-01P
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF (1,2). The cDNAs encoding GDNFRa from human, rat, chicken and mouse have been cloned recently (1-5). GDNFRa was also termed Ret ligand 1 (RETL1) or TGF-b-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRa-1 recently (5-7). GFRa-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRa and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
SourceSynthetic peptide
PurityPurified 60-70%
Concentration0.2mg/ml
FormSupplied as a lyophilized powder.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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