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You are here:Home » Antibodies » Abs to Neurotrophins » Anti -GFR alpha2, IN (Glycosylphosphadidylinositol linked Protein, GDNFRb, Ret ligand 2, RETL2)

Anti -GFR alpha2, IN (Glycosylphosphadidylinositol linked Protein, GDNFRb, Ret ligand 2,
RETL2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) (1), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRa, which is a cell surface receptor for NTN (2,3). The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently (2-7). NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2) or TGF-b-related neurotrophic factor receptor 2 (TrnR2) (4-7) and nominated as GFRa-2 recently (8). GFRa-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
Catalog #G2033-25
This polyclonal antibody can be used for detection of GFRa-2 expression by Western blot at 11000 to 1:2000 dilution. HeLa whole cell lysate can be used as positive control and a 52kD band should be detected. The amino acid sequences of immunogenic peptide are identical to those of mouse and rat and the antibody recognizes GFRa-2 of human, mouse, and rat origins.
Antibody blocking peptide G2033-25P.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified IgG
ImmunogenPeptide corresponding to amino acids 377 to 391 of human GFRa-2.
SpecificityA 52kD band should be detected. The amino acid sequences of immunogenic peptide are identical to those of mouse and rat and recognizes GFRa-2 of human, mouse and rat origins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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