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You are here:Home » Antibodies » Abs to Ligands » Anti -GFR alpha3, IN (Glycosylphosphadidylinositol linked Protein, GDNFRg, Ret ligand 3, RETL3)

Anti -GFR alpha3, IN (Glycosylphosphadidylinositol linked Protein, GDNFRg, Ret ligand 3,
RETL3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin (1). Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb (2). Following the findings of GFRa-1 and -2, a novel receptor in GFRa family was identified very recently from human and mouse and designated GFRa-3 (3-7). GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.
Catalog #G2033-50
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500 to 1:1,000
Optimal dilutions to be determined by the researcher.
Antibody blocking peptide G2033-50P
Positive ControlMurine kidney, liver or heart tissue lysates.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified IgG
ImmunogenPeptide corresponding to amino acids from 347 to 360 of murine GFRa-3
SpecificityRecognizes human GFR alpha-3 (IN). Species Crossreactivity: Human mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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