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You are here:Home » Antibodies » Abs to Ligands » Anti -GFRA3 (GDNF Family Receptor alpha-3, GDNF Receptor alpha-3, GDNFR-alpha-3, GFR-alpha-3, UNQ339/PRO538/PRO3664)

Anti -GFRA3 (GDNF Family Receptor alpha-3, GDNF Receptor alpha-3, GDNFR-alpha-3,
GFR-alpha-3, UNQ339/PRO538/PRO3664)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Highly Purified B IH
Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb. Following the findings of GFRa-1 and -2, a novel receptor in GFRa family was identified very recently from human and mouse and designated GFRa-3. GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.
Catalog #G2033-53C
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by DEAE chromatography.
ImmunogenSynthetic peptide corresponding to aa347-360 from mouse GFRA3 (KLH).
SpecificityRecognizes mouse GFRA3. Species sequence homology: Human and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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