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G2034-45 Gilvocarcin M (Anandimycin B, Toromycin B, Antibiotic 1072A) CAS: 77879-89-1

Specifications
References
CAS Number
77879-89-1
Grade
Highly Purified
Molecular Formula
C26H26O9
Molecular Weight
482.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C, protect from light
Anandimycin B, Toromycin B, Antibiotic 1072A

Gilvocarcin M is the minor analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp.. Gilvocarcin M contains a methyl group in the 8-position and is less active than the vinyl analogue (gilvocarcin V), which is thought to act as an inhibitor of human topoisomerase II. Gilvocarcin M displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research on the gilvocarcins suggests that they act as photoactivated crosslinkers of DNA to histones.

Purity: > 95% by HPLC
Solubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.
Related to: Chrysomycin A, Chrysomycin B, Gilvocarcin V, O-Deacetyl-ravidomycin
Source
Streptomyces sp.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated |gilvocarcin V in human fibroblasts. Matsumoto A. & Hanawalt P.C. Cancer Res. 2000, 60, 3921. |2. Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E. Balitz D.M. et al.. J Antibiot. |(Tokyo) 1981, 34, 1544-1555.
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