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Gilvocarcin V (Anandimycin A, Toromycin B, Antibiotic 1072B)
Gilvocarcin V (Anandimycin A, Toromycin B, Antibiotic 1072B)
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| Gilvocarcin V is the major analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp. Gilvocarcin V contains a vinyl group in the 8-position and is the most potent analogue of the complex. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. The metabolite displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research on the gilvocarcins suggests that they act as photoactiviated crosslinkers of DNA to histones. | | | Catalog # | G2034-45D | | Purity | > 95% by HPLC | | Solubility | Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. | | Related to | Chrysomycin A, Chrysomycin B, Gilvocarcin M, O-Deacetyl-ravidomycin | | CAS Number | 77879-90-4 | | Molecular Formula | C27H26O9 | | Molecular Weight | 494.5 | | Source | Streptomyces sp. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Anandimycin A, Toromycin B, Antibiotic 1072B |
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