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G2034-45D Gilvocarcin V (Anandimycin A, Toromycin B, Antibiotic 1072B) CAS: 77879-90-4

Specifications
References
CAS Number
77879-90-4
Grade
Highly Purified
Molecular Formula
C27H26O9
Molecular Weight
494.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C, protect from light
Anandimycin A, Toromycin B, Antibiotic 1072B

Gilvocarcin V is the major analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp. Gilvocarcin V contains a vinyl group in the 8-position and is the most potent analogue of the complex. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. The metabolite displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research on the gilvocarcins suggests that they act as photoactiviated crosslinkers of DNA to histones.

Purity: > 95% by HPLC
Solubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.
Related to: Chrysomycin A, Chrysomycin B, Gilvocarcin M, O-Deacetyl-ravidomycin
Source
Streptomyces sp.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated |gilvocarcin V in human fibroblasts. Matsumoto A. & Hanawalt P.C. Cancer Res. 2000, 60, 3921. |2. Photoactivated gilvocarcin V induces DNA-protein crosslinking in genes for human ribosomal RNA and |dihydrofolate reductase. Matsumoto A. et al. Photochem. Photobiol. 1994, 60, 225. |3. Activation of antitumor agent gilvocarcins by visible light. Elespuru R.K. & Gonda S.K. Science 1984, |223, 69. |4. Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E. Balitz D.M. et al. J. Antibiot. |1981, 34, 1544-1555.
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