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You are here:Home » Antibodies » Abs to Ion Channel » Anti -GIRK2 (G-Protein-activated Inward Rectifier Potassium Channel 2, GIRK-2, BIR1, Inward Rectifier K(+) Channel Kir3.2, KATP-2, Potassium Channel, Inwardly Rectifying Subfamily J Member 6, KCNJ6, KATP2, KCNJ7)

Anti -GIRK2 (G-Protein-activated Inward Rectifier Potassium Channel 2, GIRK-2, BIR1,
Inward Rectifier K(+) Channel Kir3.2, KATP-2, Potassium Channel, Inwardly Rectifying
Subfamily J Member 6, KCNJ6, KATP2, KCNJ7)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Catalog #G2035-05C
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:16,000
Western Blot: 1-3ug/ml, observed in human brain, hippocampus and substantia nigra, lysates on ~48kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-SSKLNQHAELET, from human KCNJ6, at C-terminal (NP_002231.1).
SpecificityRecognizes human KCNJ6. Species sequence homology: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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