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You are here:Home » Antibodies » Abs to Signal Transduction » Anti -Git1 (ARF GTPase-activating protein GIT1)

Anti -Git1 (ARF GTPase-activating protein GIT1)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH
ARF GTPase-activating protein GIT1 (Git1) is a multidomain protein belonging to the ARF family of small GTPases that is comprised of several protein interacting domains including: three Ankyrin repeats (ANKs), an Arf-Gap domain, a C-terminal GRK-binding domain, and a spa2 homology domain. Git1 is thought to have a role as a signaling pathway coordinator, functioning to regulate adhesion, cytoskeletal organization, and vesicle trafficking. It is also a component of several cytoplasmic complexes that contain ARHGEF6, PAK1, and PXN. In brain receptors, Git1 forms a complex with AMPA receptors, GRIP, and liprin-alpha, that is crucial to AMPA receptor targeting and the organization of synapses. Git1 expression is observed in a wide variety of tissues, with the most notable expression in the testis.
Catalog #G2035-07Q
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
Western Blot: 0.5ug/ml detects Git1 on 10ug of rat brain membrane tissue lysate.
Optimal dilutions to be determined by the researcher.
Positive ControlRat brain membrane tissue lysate.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No11C240
FormSupplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant protein corresponding to rat Git1.
SpecificityRecognizes rat Git1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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