Anti -Gli2 (GLI-Kruppel family member GLI2, THP2, Oncogene GLI2, Tax Helper Protein 2, Tax
Responsive Element 2 Holding Protein, Tax Responsive Element-25 bp Sequence Binding
Protein, Zinc Finger Protein GLI2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E |
|
| This protein belongs to the C2H2 type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors that bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. Gli2 is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes Greig cephalopolysyndactyly syndrome, Pallister Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. | | | Catalog # | G2035-53B | | Cellular Localization | Nuclear | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.91mg/ml | | Form | 0.01% Sodium Azide; 0.15M Sodium Chloride, 0.02M Potassium Phosphate. pH 7 | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide: RSKVKTEPEGLRPAS-C conjugated to KLH, corresponding to amino acids 46-60 of Human Gli2. | | Specificity | Expected to crossreact with all 4 splice variants of Human Gli as the immunogen sequence is present in all 4. Tested by Western blot on human lung, gives low background, but no band was detected. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | GLI-Kruppel family member GLI2, THP2, Oncogene GLI2, Tax helper protein 2, Tax responsive element 2 holding protein, Tax responsive element-25 bp sequence binding protein, Zinc finger protein GLI2 |
External Links
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