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You are here:Home » Biochemicals » Biochem-Mycotoxins » Gliotoxin



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Gliotoxin is a potent epithiodioxopiperazine mycotoxin produced by species in the genera Gliocladium, Aspergillus and Penicillium. At the cellular level gliotoxin has been shown to inhibit a broad range of unrelated mechanisms, such as inhibition of chymotrypsin-like activity of the 20S proteasome, Ca2+ release from mitochondria, activation of transcription factor NF- B in response to a variety of stimuli in T and B cells, anti-inflammatory activity and inhibition of farnesyltransferase and geranyl- geranyltransferase. The mode of action appears to be via covalent binding to proteins through mixed disulphide formation. Gliotoxin has been shown to inhibit a number of thiol-requiring enzymes and also displays antioxidant and immunomodulatory activity.
Catalog #G3026-01
SourceGliotoxin from Gliocladium fimbriatum.
Molecular Weight~326
SolubilitySoluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number67-99-2
Molecular FormulaC13H14N2O4S2
Molecular Weight~326
Purity~99% (HPLC)
ConcentrationNot determined
FormSupplied as a white powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

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