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You are here:Home » Antibodies » Abs to Heat Shock Proteins » Anti -Glucose Regulated Protein, NT, 75kD (Grp 75)

Anti -Glucose Regulated Protein, NT, 75kD (Grp 75)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B
Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat inducible . Grp75 is actually induced under conditions of low glucose and other nutritional and environmental stresses. Grp75 resides primarily in the mitochondrial matrix, where it collaborates with Hsp60 in the re-folding of proteins translocated into this organelle. Related forms may also be found in the cytosol or on the surface of the extracellular membrane. Other Grp75 functions include its ability to inactivate the tumor suppressor p53. Studies have found that Grp75 is over-expressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation. Grp75 is also implicated in cell
aging, as its overexpression appears to prolong the life span of human fibroblasts. And finally, like its E.coli homolog DnaK, GRP75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone.
Catalog #G3057-12
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500 using ECL at 1-2 minute exposure.
Optimum dilutions to be determined by researcher.
Secondary AntibodyRabbit IgG (HRP) diluted at 1:100,000
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid.
PuritySupplied as a liquid.
ImmunogenN-terminal fragment of human Grp 75 (aa47-69)
SpecificityRecognizes human Glucose Regulated Protein 75. Species crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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