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You are here:Home » Antibodies » Abs to Heat Shock Proteins » Anti -Glucose Regulated Protein 75 (Grp75, HSPA9, heat shock 70kDa protein 9 (mortalin), CSA, HSPA9B, MGC4500, Mortalin, MOT, MOT2, mot-2, mthsp75, MTHSP75, PBP74, Peptide-binding protein 74, Stress-70 protein, mitochondrial)

Anti -Glucose Regulated Protein 75 (Grp75, HSPA9, heat shock 70kDa protein 9 (mortalin),
CSA, HSPA9B, MGC4500, Mortalin, MOT, MOT2, mot-2, mthsp75, MTHSP75, PBP74, Peptide-binding
protein 74, Stress-70 protein, mitochondrial)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH
Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat inducible (1, 2). Grp75 is actually induced under conditions of low glucose and other nutritional and environmental stresses. Grp75 resides primarily in the mitochondrial matrix,
where it collaborates with Hsp60 in the re-folding of proteins translocated into this organelle (3, 4). Related forms may also be found in the cytosol or on the surface of the extracellular membrane. Other Grp75 functions include its ability to inactivate the tumor suppressor p53 (5). Studies have found that Grp75 is over-expressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation (6). Grp75 is also implicated in cell
aging, as its overexpression appears to prolong the life span of human fibroblasts (7). And finally, like its E.coli homolog DnaK (8), GRP75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone (9, 10).
Catalog #G3057-12B
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10F705
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, 50% glycerol.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to human Grp75.
SpecificityRecognizes Grp75. SpeciesCcross-Reactivity: rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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