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Anti -Glucose Regulated Protein 78 (Grp78, BiP)
Anti -Glucose Regulated Protein 78 (Grp78, BiP)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| Grp78, a 78kD glucose-regulated protein, also known as BiP or immunoglobulin heavy chain binding protein, is a stress-response protein which is induced by agents or conditions that adversely affect endoplasmic reticulum (ER) function (2). This protein is essential for the proper glycosylation, folding and assembly of many membrane bound and secreted proteins (3). Grp78 is critical for maintenance of cell homeostasis and the prevention of apoptosis (4). Grp78 protein levels have been shown to be a reliable biomarker of hypoglycermia (5) as well as serving a neuroprotective function in neurons exposed to glutamate and oxidative stress (2). Grp78 levels are reduced in the brains of Alzheimer’s Disease patients and decreased expression of Grp78 is found associated with missense mutations in the human presenilin-1 (PS1) gene (6). The induction of the Grp78 protein has been associated with the development of drug-resistance to anti-tumor drugs (7). | | | Catalog # | G3057-20 | | Applications | Suitable for use in Western Blot. Other applications have not been tested. | | Recommended Dilution | | | Western Blot (ECL): 1:1000 | | Optimal dilutions to be determined by the researcher. | | | | Positive Controls: | | G3057-22: Recombinant Hamster Grp78 Protein. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Rat | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa 645-654 of rat Grp78 (KLH). | | Specificity | Recognizes rat Grp78 at ~78kD Species Crossreactivity: mouse, bovine, hamster, monkey, rabbit, Xenopus, and fungus (Cryphonectria parasitica). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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