Anti -GLUT 1 (Erythrocyte/brain HepG2 glucose transporter, Glucose transporter type 1,
Glucose transporter type 1 erythrocyte/brain, GLUT, GLUTB, GT1, GTG1, Gtg3, SLC2A1,
Solute carrier family 2 facilitated glucose transporter member 1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B IP IH |
|
| Seven types of glucose transport carrier proteins designated as Glut 1-7 facilitate glucose transport across the cell membrane. Molecular cloning of glucose transporters have identified a family of closely related genes that encodes at least 7 proteins exhibiting high degree of amino acid homology (45%-65%) all in the molecular weight range of 40-60kD. Individual members of the Glut family have predicted secondary structure characteristic of 12 membrane spanning domains of other transport carriers. Majority of the differences in sequence homology in Glut proteins occur at 4 hydrophilic domains that may play a role in distinct tissue-specific pattern of expression and targeting. All Glut proteins are glycosylated at or near the C-terminus and are present on either cell surface or in intracellular sites. Some transporters exhibit dynamic trafficking between intracellular storage sites and plasma membranes in response to various stimuli. In some tissues Glut proteins are asymmetrically distributed between apical and basolateral membranes as in blood brain barrier and blood testis barriers. | | | Catalog # | G3900-03 | | Applications | Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | ELISA: 1:12,000 | | Western Blot: 1:5000. Predicted MW is ~50kD. | | Immunohistochemistry: 1:200 | | Immunoprecipitation: 2ul will immunoprecipitate 80-85% Glut 1 from rat hippocampal membranes. | | Optimal dilutions to be determined by the researcher. | | Positive Control | Rat hippocampal plasma membranes. The antibody labels glucose transporter (Glut 1) species from rat | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid, 0.02% sodium azide. | | Purity | Purified by affinity chromatography. | | Immunogen | Synthetic peptide corresponding to [C]GLFHPLGADSQV, from human GLUT 1. Cellular Localization: Integral membrane protein. Localizes primarily at the cell surface (by similarity). | | Specificity | Recognizes human GLUT1. Species crossreactivity: rat. Does not react with mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Erythrocyte/brain HepG2 glucose transporter, Glucose transporter type 1, Glucose transporter type 1 erythrocyte/brain, GLUT, GLUTB,, GT1, GTG1, Gtg3, SLC2A1, Solute carrier family 2 facilitated glucose transporter member 1 |
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