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You are here:Home » Antibodies » Abs to Glucose Transporters » Anti -GLUT 4 (Glucose Transporter 4, Glucose Transporter Type 4 Insulin-responsive, GLUT4, GLUT-4, Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 4, SLC2A4)

Anti -GLUT 4 (Glucose Transporter 4, Glucose Transporter Type 4 Insulin-responsive, GLUT4,
GLUT-4, Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 4, SLC2A4)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B FC
Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters. Molecular cloning of these glucose transporters has identified a family of closely related genes that encodes at least 7 proteins (Glut-1 to Glut-13, Mol. Wt. 40-80kD) and Sodium glucose co-transporter- 1 (SGLT-1, 662aa; ~75kD). Individual member of this family have identical predicted secondary structures with 12 transmembrane domains. Both N and C-termini are predicted to be cytoplasmic. Most differences in sequence homology exist within the four hydrophilic domains that may play a role in tissue- specific targeting. Glut isoforms differ in their tissue expression, substrate specificity and kinetic characteristics. Glut-1 mediates glucose transport into red cells, and throughout the blood brain barrier, and supply glucose to most cells. Glut-2 provides glucose to the liver and pancreatic cells. Glut-3 is the main transporter in neurons, whereas Glut-4 (mouse/human 509aa) is primarily expressed in muscle and adipose tissue and regulated by insulin.
Catalog #G3900-50L
ApplicationsSuitable for use in Western Blot and Flow Cytometry. Other applications not tested.
Recommended DilutionWestern Blot: 1-5ug/ml (chemiluminescence)
Flow Cytometry: ~10ug/ml (10e5 cells) Perform the antibody binding in small volume of ~200ul.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11C104
HostMouse
SourceRat
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to rat glut-4, Cytoplasmic domain.
SpecificityRecognizes rat Glut-4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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