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Anti -GLUT 4 (Glucose Transporter 4, Glucose Transporter Type 4 Insulin-responsive, GLUT4, GLUT-4, Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 4, SLC2A4)
Anti -GLUT 4 (Glucose Transporter 4, Glucose Transporter Type 4 Insulin-responsive, GLUT4,
GLUT-4, Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 4, SLC2A4)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP IH IF |
|
| Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters. Molecular cloning of these glucose transporters has identified a family of closely related genes that encodes at least 7 proteins (Glut-1 to Glut-13, Mol. Wt. 40-80kD) and Sodium glucose co-transporter- 1 (SGLT-1, 662aa; ~75kD). Individual member of this family have identical predicted secondary structures with 12 transmembrane domains. Both N and C-termini are predicted to be cytoplasmic. Most differences in sequence homology exist within the four hydrophilic domains that may play a role in tissue- specific targeting. Glut isoforms differ in their tissue expression, substrate specificity and kinetic characteristics. Glut-1 mediates glucose transport into red cells, and throughout the blood brain barrier, and supply glucose to most cells. Glut-2 provides glucose to the liver and pancreatic cells. Glut-3 is the main transporter in neurons, whereas Glut-4 (mouse/human 509aa) is primarily expressed in muscle and adipose tissue and regulated by insulin. | | | Catalog # | G3900-50N | | Applications | Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunofluorescence: 2.5-5ug/ml | | Immunohistochemistry (Formalin-fixed, paraffin-embedded): 10-15ug/ml | | Immunohistochemistry (Frozen): 2.5-5ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 1F8 | | Host | Mouse | | Source | Rat | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | | Immunogen | Partially purified vesicles | | Specificity | Recognizes rat SLC2A4. Species sequence homology: Human, monkey, mouse and rabbit. Does not recognize canine SLC2A4. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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