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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified E B

Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters. Molecular cloning of these glucose transporters has identified a family of closely related genes that encodes at least 7 proteins (GLUT 1 to GLUT 7, MW. 40-60kD) and Sodium glucose co-transporter-1 (SGLT-1, 662 amino acids; ~75kD). Individual member of this family have identical predicted secondary structures with 12 transmembrane domains. Both N- and C-termini are predicted to be cytoplasmic. Most differences in sequence homology exist within the four hydrophilic domains that may play a role in tissue-specific targeting.
GLUT isoforms differ in their tissue expression, substrate specificity and kinetic characteristics. GLUT 6/SLC2A6, originally described as GLUT 9 has been reassigned as GLUT 6. GLUT 6 (human 507aa; ~48kD; chromosome 9q34) is most closely related to GLUT 8 (~45% homology). It is highly expressed in brain, spleen and peripheral leukocytes.
Catalog #	G3900-75K
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution	ELISA: 0.5-1ug/ml, Control peptide (Cat# G3900-75) can be used to coat ELISA plates at 1ug/ml.
	Western Blot:1-10ug/ml using ECL.
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in 100mM Tris, pH 7.5, 0.2% BSA, 0.05% sodium azide, 40% glycerol.
Purity	Purified by immunoaffinity chromatography.
Immunogen	A 16aa synthetic peptide sequence near the cytoplasmic, C-terminus of human GLUT 6, coupled to KLH
Specificity	Recognizes human GLUT 6.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.