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You are here:Home » Antibodies » Abs to Enzymes, Decarboxylase » Anti -Glutamate Decarboxylase 65 (65kD Glutamic Acid Decarboxylase, GAD 65, GAD65, GAD-65, Glutamate Decarboxylase 2, GAD 2, GAD2, GAD-2, MGC161605, MGC161607)

Anti -Glutamate Decarboxylase 65 (65kD Glutamic Acid Decarboxylase, GAD 65, GAD65, GAD-65,
Glutamate Decarboxylase 2, GAD 2, GAD2, GAD-2, MGC161605, MGC161607)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B
Adults express two forms of glutamate decarboxylase (GAD), GAD65 and GAD67, which are encoded by different independently regulated genes. Both are expressed in most GABA containing neurons. GAD65 appears to be targeted to the membrane and nerve endings; while GAD67 is more widely distributed throughout the cell. GAD65 preferentially synthesizes GABA for vesicular release and GAD67 preferentially synthesizes cytoplasmic GABA. GAD65 is predominantly expressed in pancreatic beta cells and autoantibodies to GAD65 are strongly associated with Insulin-dependent diabetes mellitus (IMDM).
Catalog #G4000-01K
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:10-1:250
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic peptide corresponding to aa516-528, (C)-L-E-D-N-E-E-R-M-S-R-L-S-K, from human Glutamate Decarboxylase 65, conjugated to KLH.
SpecificityRecognizes human Glutamate Decarboxylase 65.
Species Sequence HomologyBovine, chicken, chimpanzee, canine, equine, mouse, porcine, rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEC=4.1.1.15, Glutamate Decarboxylase 65kD Isoform, Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa)


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