You are here:Home
»
Antibodies
»
Abs to Proteins
»
Anti -Glycoprotein VI (GPVI, GP6, Platelet glycoprotein VI precursor, MGC138168)
Anti -Glycoprotein VI (GPVI, GP6, Platelet glycoprotein VI precursor, MGC138168)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B IH IF |
|
| Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcR?) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR?, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds. | | | Catalog # | G4906-01 | | Applications | Suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Western Blot: 1ug/ml | | Immunofluorescence: 20ug/ml | | Immunohistochemistry: 10ug/ml | | Optimal dilutions to be determined by the researcher. | | Recommended Positive Control | A20 Cell Lysate | | Recommended Control Peptide | G4906-01D | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide | | Purity | Purified by immunoaffinity chromatography | | Immunogen | Synthetic peptide corresponding to 15aa near the carboxy terminus of the human GPVI (Accession #: NP_057447). | | Specificity | Recognizes human GPVI. Species Crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
