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You are here:Home » Antibodies » Abs to Enzymes, Decarboxylase » Anti -GLUL (GLNS, Glutamate-ammonia ligase, Glutamate decarboxylase, Glutamine synthetase, GS, PIG43, PIG59)

Anti -GLUL (GLNS, Glutamate-ammonia ligase, Glutamate decarboxylase, Glutamine synthetase,
GS, PIG43, PIG59)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Glutamine Synthetase catalyzes the conversion of ammonia and glutamate to glutamine. This reaction consumes a molecule of ATP:Glutamate + NH4+ + ATP , and produces, Glutamine + ADP + Pi. It is found in astrocytes as an octamer of identical 45kD subunits. The function of Glutamine Synthetase is the detoxification of brain ammonia. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of Glutamine Synthetase in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of Glutamine Synthetase is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. On the other hands, the level of expression of Glutamine Synthetase is increased during ischemia in vivo or hypoxia in culture.
Catalog #G7121-04C
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No2B12
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant corresponding to aa1-374 from human GLUL with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human GLUL.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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