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You are here:Home » Antibodies » Abs to Enzymes, Peroxidase » Anti -Glutathione Peroxidase 1 (GPX1, GPx-1, Cellular Glutathione Peroxidase, HGNC:4553, GSHPX1, GSHPx-1 MGC14399, MGC88245)

Anti -Glutathione Peroxidase 1 (GPX1, GPx-1, Cellular Glutathione Peroxidase, HGNC:4553,
GSHPX1, GSHPx-1 MGC14399, MGC88245)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. It has been reported that the protein encoded by this gene protects from CD95-induced apoptosis in cultured breast cancer cells and inhibits 5-lipoxygenase in blood cells, and its overexpression delays endothelial cell growth and increases resistance to toxic challenges. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Catalog #G8127-11A
Positive Control Human Liver lysate
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide, C-REALPAPSDDATA, representing the internal region of the human protein according to NP_000572.2.
SpecificitySpecies Crossreactivity: Human. Other species not tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesGPX1, GPx-1, Cellular Glutathione Peroxidase, HGNC:4553, GSHPX1, GSHPx-1 MGC14399, MGC88245


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