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You are here:Home » Antibodies » Abs to Enzymes, Peroxidase » Anti -Glutathione Peroxidase 1 (GPx-1, GSHPx-1, Cellular Glutathione Peroxidase, GPX1)

Anti -Glutathione Peroxidase 1 (GPx-1, GSHPx-1, Cellular Glutathione Peroxidase, GPX1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B IP IH
Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic /mitochondrial GPx1 (cGPx) is a seleniumdependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PHGPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site.
Catalog #G8127-11G
ApplicationsSuitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:5000
Immunohistochemistry (Formalin-fixed, paraffin-embedded): 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No13B2AF
HostMouse
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in HEPES, 0.15M sodium chloride, 0.01% BSA, 0.03% sodium azide, 50% glycerol.
PurityPurified.
ImmunogenRecombinant corresponding to mouse GPX1, expressed in E. coli.
SpecificityRecognizes mouse GPX1. Species sequence homology: Human and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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