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You are here:Home » Antibodies » Abs to Receptors » Anti -Glycine Receptor, alpha1 (GLRA1, lycine receptor 48kD subunit, Glycine receptor strychnine-binding subunit, Glycine receptor subunit alpha-1, MGC138878, MGC138879, STHE)

Anti -Glycine Receptor, alpha1 (GLRA1, lycine receptor 48kD subunit, Glycine receptor
strychnine-binding subunit, Glycine receptor subunit alpha-1, MGC138878, MGC138879, STHE)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP IH
Glycine is an important inhibitory neurotransmitter in the mammalian central nervous system, especially in the brainstem and spinal cord. It acts by binding to anion-conducting glycine receptors that belong to a superfamily of ligand-gated ion channels. Glycine receptors were first purified as strychnine binding sites in membrane fractions of adult spinal cord from rats (1). These strychnine-sensitive binding sites are different from the strychnine-insensitive binding sites found in the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors. Adult glycine receptors are heterodimers composed of two subunits of 48kD and 58kD, denoted as a1 and b subunits. Fetal glycine receptors are homomers composed of a2 subunits.
Catalog #G8167-01
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Immunohistochemistry (Frozen): 1:1000
Optimal dilution determined by the researcher.
Positive controlCell extracts containing recombinant human glycine receptors and homogenates of rat spinal cord.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a lyophilized powder from ammonium bicarbonate. Reconstitute in 50ul sterile PBS.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide from the amino terminus of the human alpha 1 glycine receptor subunit (ARSATKPMSPSDFLDKLMGC) (KLH). Cellular Localization: Cell membrane.
SpecificityRecognizes human Glycine Receptor, alpha1. Specific to the a1 and a2 subunits of the glycine receptor. Species Crossreactivity: Mouse, rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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