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Anti -Glycine Receptor, alpha1 (GLRA1, lycine receptor 48kD subunit, Glycine receptor strychnine-binding subunit, Glycine receptor subunit alpha-1, MGC138878, MGC138879, STHE)
Anti -Glycine Receptor, alpha1 (GLRA1, lycine receptor 48kD subunit, Glycine receptor
strychnine-binding subunit, Glycine receptor subunit alpha-1, MGC138878, MGC138879, STHE)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IP IH |
|
| Glycine is an important inhibitory neurotransmitter in the mammalian central nervous system, especially in the brainstem and spinal cord. It acts by binding to anion-conducting glycine receptors that belong to a superfamily of ligand-gated ion channels. Glycine receptors were first purified as strychnine binding sites in membrane fractions of adult spinal cord from rats (1). These strychnine-sensitive binding sites are different from the strychnine-insensitive binding sites found in the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors. Adult glycine receptors are heterodimers composed of two subunits of 48kD and 58kD, denoted as a1 and b subunits. Fetal glycine receptors are homomers composed of a2 subunits. | | | Catalog # | G8167-01 | | Applications | Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000 | | Immunohistochemistry (Frozen): 1:1000 | | Optimal dilution determined by the researcher. | | Positive control | Cell extracts containing recombinant human glycine receptors and homogenates of rat spinal cord. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a lyophilized powder from ammonium bicarbonate. Reconstitute in 50ul sterile PBS. | | Purity | Purified by affinity chromatography. | | Immunogen | Synthetic peptide from the amino terminus of the human alpha 1 glycine receptor subunit (ARSATKPMSPSDFLDKLMGC) (KLH). Cellular Localization: Cell membrane. | | Specificity | Recognizes human Glycine Receptor, alpha1. Specific to the a1 and a2 subunits of the glycine receptor. Species Crossreactivity: Mouse, rat | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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