Anti -Golgi protein 58K (Formiminotransferase cyclodeaminase, FTCD, Glutamate
formiminotransferase, LCHC1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| 58K protein antibodies are excellent for use as markers for the Golgi complex. The 58K protein has been identified as being FTCD, a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency; also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities. | | | Catalog # | G8577-50D | | Cellular Localization | Cytoplasmic and Golgi Apparatus | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:32,000 | | Western Blot: 0.03-0.1ug/ml. Predicted molecular weight: 59kD. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | | | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in TBS, pH 7.2, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide: C-LREQGRGKDQPGRL, from the internal region of the protein sequence according to NP_006648; NP_996848. | | Specificity | Expected to recognize both reported isoforms. Species Crossreactivity: Reacts with Human. Predicted to react with Mouse (100% identity with immunogen), Rat (100% identity with immunogen), Chicken (84% identity with immunogen), Zebrafish (90% identity with immunogen) and porcine (100% identity with immunogen) due to sequence homology. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Formiminotransferase cyclodeaminase, FTCD, Glutamate formiminotransferase, LCHC1 |
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