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You are here:Home » Antibodies » Abs to Golgi Proteins » Anti -Golgi protein 58K (Formiminotransferase cyclodeaminase, FTCD, Glutamate formiminotransferase, LCHC1)

Anti -Golgi protein 58K (Formiminotransferase cyclodeaminase, FTCD, Glutamate
formiminotransferase, LCHC1)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
58K protein antibodies are excellent for use as markers for the Golgi complex. The 58K protein has been identified as being FTCD, a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency; also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.
Catalog #G8577-50D
Cellular Localization Cytoplasmic and Golgi Apparatus
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Western Blot: 0.03-0.1ug/ml. Predicted molecular weight: 59kD.
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in TBS, pH 7.2, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: C-LREQGRGKDQPGRL, from the internal region of the protein sequence according to NP_006648; NP_996848.
SpecificityExpected to recognize both reported isoforms. Species Crossreactivity: Reacts with Human. Predicted to react with Mouse (100% identity with immunogen), Rat (100% identity with immunogen), Chicken (84% identity with immunogen), Zebrafish (90% identity with immunogen) and porcine (100% identity with immunogen) due to sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesFormiminotransferase cyclodeaminase, FTCD, Glutamate formiminotransferase, LCHC1


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