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You are here:Home » Antibodies » Abs to G Proteins » Anti -G Protein, alpha (Gai1)

Anti -G Protein, alpha (Gai1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
GTP-binding proteins (G-proteins) play a critical role in signal transduction by coupling receptors to effectors. The intracellular consequences of G-protein activation include second messenger generation (such as cyclic AMP, calcium and diacylglycerol), protein phosphorylation, ion channel activation, gene induction, cell growth and differentiation. Gi belongs to the pertussis toxin sensitive G-proteins. Gi consists of three different subtypes of alpha subunits (ai1, ai2, and ai3).
Catalog #G8599-01
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Positive ControlIMR-5 cells; brain
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No0.N.305
HostMouse
SourceRat
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.1% sodium azide, before addition of glycerol to 40%. Also available without BSA and azide. See G8599-01X.
PurityPurified by Protein A affinity chromatography.
ImmunogenPartially purified Gai1 protein from rat brain (39-42kD). Cellular Localization: Cell membrane.
SpecificityRecognizes Rat Gai1. Does not crossreact with Transducin, Gao, Gai2, Gai3, or Gas. ADP-ribosylation of ai1 proteins does not alter the reactivity. Species Crosseactivity: mouse, bovine, guinea pig and human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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