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You are here:Home » Antibodies » Abs to G Proteins » Anti -GBL (G-Protein beta Subunit-like, Gable, Mammalian Lethal with SEC13 Protein 8, mLST8, LST8, MGC111011, Protein GbetaL, Target of Rapamycin Complex Subunit LST8, TORC Subunit LST8)

Anti -GBL (G-Protein beta Subunit-like, Gable, Mammalian Lethal with SEC13 Protein 8,
mLST8, LST8, MGC111011, Protein GbetaL, Target of Rapamycin Complex Subunit LST8, TORC
Subunit LST8)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
GßL (G protein beta protein subunit-like) is a member of a signaling pathway that regulates mammalian cell growth in response to the presence of nutrients and growth factors. It binds to the kinase domain of TOR (Target of rapamycin, also known as mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation. TOR is normally associated with GßL and an additional regulatory protein RAPTOR, allowing TOR to control protein biosynthesis. The binding of GßL to TOR stimulates TOR's kinase activity towards downstream proteins such as RPS6K (ribosomal protein S6 kinase) and the translation factor 4E-BP1 which leads to increased protein translation and cell growth.
Catalog #G8600-02Y
ApplicationsSuitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:250-1:500
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide selected from the center region of human GBL (KLH).
SpecificityRecognizes human GBL.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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