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Anti -G Protein Coupled Receptor 15 (GPR15, Brother of Bonzo, BoB, MGC126828, MGC126830)
Anti -G Protein Coupled Receptor 15 (GPR15, Brother of Bonzo, BoB, MGC126828, MGC126830)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH |
|
| G protein-coupled receptor GPR15 is an Orphan-A GPCR with an unknown ligand. Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to biological phenotype. The chemokine receptors CCR5 and CXCR4 are the major coreceptors that, together with CD4, govern HIV-1 entry into cells. Some HIV-1, HIV-2, and SIV isolates of different genetic subtypes and biological phenotypes use BOB/GPR15 for productive infection, suggesting that this cofactor may play a role in HIV-1 pathogenesis and transmission. GPR15 expression has been reported in CD4(+) T lymphocytes, alveolar macrophages, and the basal surface of the small intestinal epithelium. ESTs have been isolated from normal brain and kidney cancer libraries. | | | Catalog # | G8600-19G | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 10-20ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human colon, surface epithelium | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.7, 0.01% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the 1st cytoplasmic domain of human GPR15. | | Specificity | Recognizes human GPR15. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | G Protein-coupled Receptor 15, G-protein Coupled Receptor 15 |
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