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You are here:Home » Antibodies » Abs to G Proteins » Anti -GPR39 (G-Protein Coupled Receptor 39, GPCR39)

Anti -GPR39 (G-Protein Coupled Receptor 39, GPCR39)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B
Control of appetite involves a number of gastrointestinal hormones that belong to the ghrelin-motilin ligand family that either stimulate food intake and gastric emptying or inhibit these responses. These hormones have been the focus of intense research in hopes of developing drug therapy for gastrointestinal and eating disorders.
Catalog #G8600-43H
GPR39 is a G protein-coupled receptor (GPCR) isolated from human genomic libraries. It is sequentially distantly related to the growth hormone secretagogue receptor (ghrelin) and neurotensin receptors. Its endogenous ligand was unknown until 2005, when an amidated 23aa peptide, obestatin, was found to bind to it specifically. Obestatin was found through bioinformatics studies as a peptide, part of the ghrelin precursor. Interestingly, these two peptides appear to have opposite effects. While ghrelin stimulates appetite by acting on its receptor in the arcuate nucleus, obestatin suppresses appetite.
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsELISA: 1:100,000 using 50-100ng control peptide G8600-43G per well.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypePolyclonal
HostRabbit
SourceMouse
ConcentrationNot determined.
FormSupplied as a lyophilized powder, 0.05% sodium azide. Reconstitute in 100ul sterile PBS.
PuritySerum
ImmunogenSynthetic peptide corresponding to 17aa from mouse GPR39 conjugated to KLH (Q5U431). Sequence Homology
SpecificityRecognizes mouse GPR39. Epitope: ~midregion, extracellular
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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