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You are here:Home » Antibodies » Abs to Receptors, Cholinergic » Anti -GPR109B (G-protein Coupled Receptor 109B, G-protein Coupled Receptor HM74, G-protein Coupled Receptor HM74B, Niacin Receptor 2, Nicotinic Acid Receptor 2, HM74B, NIACR2)

Anti -GPR109B (G-protein Coupled Receptor 109B, G-protein Coupled Receptor HM74, G-protein
Coupled Receptor HM74B, Niacin Receptor 2, Nicotinic Acid Receptor 2, HM74B, NIACR2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
GPR109B is a membrane protein belonging to family 1 of G protein-coupled receptor (GPCR) is homologous to GPR109A. GPR109B, a potential 7 transmembrane-spanning receptor, shows a significant homology to B2 bradykinin receptor and to thrombin receptor. GPR109B mediates the anti-lipolytic and lipid-lowering effect of nicotinic acid by acting as a nicotinic acid receptor and results in a G protein-mediated decrease in cAMP levels and hence are promising targets for future pharmacotherapy. It is known to show highest expression in spleen followed by lymphocytes and adipose tissue.
Catalog #G8601-13M
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Immunohistochemistry (paraffin): 10ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman liver lysate.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa1-50 of human GPR109B.
SpecificityRecognizes human GPR109B. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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