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You are here:Home » Growth Factors, Cytokines » Growth Factors-GM-CSF » Granulocyte Macrophage Colony Stimulating Factor, Recombinant, Mouse (GM-CSF, Burst Promoting Activity, CMCSF, Colony Stimulating Factor 2, CSF Alpha, Eosinophil Colony Stimulating Factor, Granulocyte Macrophage Colony Stimulating Factor, Molgramostin, Pl

Granulocyte Macrophage Colony Stimulating Factor, Recombinant, Mouse (GM-CSF, Burst
Promoting Activity, CMCSF, Colony Stimulating Factor 2, CSF Alpha, Eosinophil Colony
Stimulating Factor, Granulocyte Macrophage Colony Stimulating Factor, Molgramostin, Pl

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Specifications

M-GM-CSF is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages. GM-CSF receptors shows significant homologies with other receptors for hematopoietic growth factors, including IL2-beta, IL-3, IL-6, IL-7, EPO and the Prolactin receptors.
Catalog #G8950-11A
Biological ActivityMurine GM-CSF is fully biologically active when compared to standard. The ED50 as determined by the dose-dependent proliferation of murine FDC-P1 cell line is 3-5pg/ml..
Amino Acid SequenceMAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, 0.1% BSA or HSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight14.3kD
SourceE. coli
Purity~ 95% as determined by HPLC; Reducing and non-reducing SDS-PAGE (UV 280NM) spectroscopy at 280nm.
FormSupplied as a lyophilized powder from 10mM acetic acid. Reconstitute with sterile ddH2O, and a carrier protein (0.1% HSA or BSA) to a concentration of 0.1mg/ml, which can be further diluted into other aqueous solutions.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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