GM-CSF, Recombinant, Human (Granulocyte-macrophage Colony-stimulating Factor, GM-CSF,
Colony-stimulating Factor, CSF, Molgramostin, Sargramostim, CSF2, GMCSF)
Pricing
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| Human GM-CSF is a 24kD glycoprotein produced by a variety of cell types, including T and B lymphocytes, macrophages, keratinocytes, eosinophils, neutrophils, and endothelial cells in response to cytokine or inflammatory stimuli. GM-CSF was initially identified on the basis of its capacity to stimulate the clonal proliferation of myeloid precursors in vitro. GM-CSF promotes a Th1 biased immune response, allergic inflammation, and the development of autoimmunity. GM-CSF are particularly effective as antitumor vaccines. GM-CSF regulates multiple biological activities through activation of the GM-CSF receptor (GMCSFR), a member of the type I cytokine receptor group comprising a and b subunits. | | | Catalog # | G8951-26G | | Source | Recombinant corresponding to aa18-144, from human GM-CSF, expressed in E.coli. | | Molecular Weight | ~14.6kD | | Endotoxin Level | 1EU/1ug (LAL) | | Specific Activity | The ED50 for this effect is typically 10-40pg/ml. Measured in a cell proliferation assay using the human growth factor-dependent cell line TF-1. | | Storage and Stability | Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | Molecular Weight | ~14.6kD | | Source | E.coli | | Purity | ~95% (SDS-PAGE) | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 10% glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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