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You are here:Home » Growth Factors, Cytokines » Growth Factors-GM-CSF » GM-CSF, Recombinant, Human (Granulocyte-macrophage Colony-stimulating Factor, GM-CSF, Colony-stimulating Factor, CSF, Molgramostin, Sargramostim, CSF2, GMCSF)

GM-CSF, Recombinant, Human (Granulocyte-macrophage Colony-stimulating Factor, GM-CSF,
Colony-stimulating Factor, CSF, Molgramostin, Sargramostim, CSF2, GMCSF)

Pricing

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Specifications

Human GM-CSF is a 24kD glycoprotein produced by a variety of cell types, including T and B lymphocytes, macrophages, keratinocytes, eosinophils, neutrophils, and endothelial cells in response to cytokine or inflammatory stimuli. GM-CSF was initially identified on the basis of its capacity to stimulate the clonal proliferation of myeloid precursors in vitro. GM-CSF promotes a Th1 biased immune response, allergic inflammation, and the development of autoimmunity. GM-CSF are particularly effective as antitumor vaccines. GM-CSF regulates multiple biological activities through activation of the GM-CSF receptor (GMCSFR), a member of the type I cytokine receptor group comprising a and b subunits.
Catalog #G8951-26G
SourceRecombinant corresponding to aa18-144, from human GM-CSF, expressed in E.coli.
Molecular Weight~14.6kD
Endotoxin Level 1EU/1ug (LAL)
Specific ActivityThe ED50 for this effect is typically 10-40pg/ml. Measured in a cell proliferation assay using the human growth factor-dependent cell line TF-1.
Storage and StabilityAliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight~14.6kD
SourceE.coli
Purity~95% (SDS-PAGE)
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 10% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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